Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification

Toll-Like Receptors, Inflammation, and Calcific Aortic Valve Disease

Inflammation, the primary response of innate immunity, is essential to initiate the calcification process underlying calcific aortic valve disease (CAVD), the most prevalent valvulopathy in Western countries. The pathogenesis of CAVD is multifactorial and includes inflammation, hemodynamic factors, fibrosis, and active calcification. In the development of CAVD, both innate and adaptive immune r...

Aortic valve calcification – the role of inflammation and fibrosis

Background Pathogenesis of aortic valve calcificationis a multifunctional processassociated with various risk factors, while heart valve replacement is the only established treatment. Unfortunately, the real mechanism of the valve calcification remains still unknown. Herewith, we investigate the changes in molecular levelof aortic valve tissues in order to characterize the mineral deposits and ...

Assessment of Valvular Calcification and Inflammation by Positron Emission Tomography in Patients with Aortic Stenosis Running title: Dweck et al.; Calcification and inflammation in aortic stenosis

Notch Signaling in Congenital and Acquired Aortic Valve Disease

Calcific aortic valve disease represents the predominant pathology of tricuspid (trileaflet) and bicuspid aortic valves in developed countries (Ladich et al., 2011). Accounting for approxi‐ mately half of anatomically isolated aortic stenosis and 25 percent of patients with aortic regurgitation (Roberts, 1970), calcific bicuspid aortic valves requiring surgical intervention present at least two...

Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction.

OBJECTIVE Calcific aortic valve disease (CAVD) is a significant cardiovascular disorder, and controversy exists as to whether it is primarily a dystrophic or osteogenic process in vivo. In this study, we sought to clarify the mechanism of CAVD by assessing a genetic mutation, Notch1 heterozygosity, which leads to CAVD with 100% penetrance in humans. APPROACH AND RESULTS Murine immortalized No...